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KMID : 0363220090470101141
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Korean Journal of Dermatology
2009 Volume.47 No. 10 p.1141 ~ p.1148
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The Efficacy of Topical Photodynamic Therapy with a Light-Emitting Diode(LED) Device for Recalcitrant Hand and Foot Warts
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Kim Tae-Yoon
Yoon Moon-Soo
Kim Dong-Hyun
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Abstract
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Background: The treatment of recalcitrant hand and foot warts is a therapeutic challenge. Aminolevulinic acid-photodynamic therapy (ALA-PDT) has recently been reported to show high curative rates, but there has been relatively little research on this in Korea.
Objective: The purpose of this study is to evaluate the efficacy and side effects of ALA-PDT with using a light emitting diode (LED) device and 20% 5-aminolevulinic acid for the treatment of recalcitrant hand and foot warts.
Methods: One hundred four warts from 19 patients were selected and then treated with PDT using 20% ALA and a 633-nm LED device until all the lesions had cleared. The light dose was 90∼120 J/cm2.
Results: The mean number of treatment sessions was 9.1; those for the foot warts and hand warts were 11.2 and 6.5, respectively. After the treatment sessions, a complete response was seen for 55 of 104 warts (52.9%), a partial response-good was seen for 21 of 104 warts (20.2%), a partial response-poor was seen for 18 of 104 warts (17.3%), and no response was seen for 10 of 104 (9.6%). All the patients reported pain during the treatment and 11 patients (57.9%) also had pain at 24 hours after treatment. Post-inflammatory hyperpigmentation occurred in 4 of 19 patients (21.1%).
Conclusion: ALA-PDT can be a non-invasive and effective treatment modality for recalcitrant hand and foot warts.
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KEYWORD
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Photodynamic, Recalcitrant, Wart
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